Keratocystic Odontogenic Tumor (Odontogenic Keratocyst) – Discuss Dentistry https://demo.discussdentistry.com/forums/topic/keratocystic-odontogenic-tumor-odontogenic-keratocyst/feed/ Fri, 14 Nov 2025 04:37:08 +0000 https://bbpress.org/?v=2.6.12 en-US https://demo.discussdentistry.com/forums/topic/keratocystic-odontogenic-tumor-odontogenic-keratocyst/#post-14409 <![CDATA[Re: Keratocystic Odontogenic Tumor (Odontogenic Keratocyst)]]> https://demo.discussdentistry.com/forums/topic/keratocystic-odontogenic-tumor-odontogenic-keratocyst/#post-14409 Thu, 25 Nov 2010 12:30:43 +0000 sushantpatel_doc Critical factors responsible for the recurrence of keratocystic odontogenic tumor (KCOT) were examined. Methods: The clinicopathological features were retrospectively studied in 74 patients with 75 sporadic KCOTs. From the 75 KCOTs, 23 were examined for the expression of Sonic Hedgehog (SHH), Patched and Smoothened (SMO) by immunohistochemistry. Results: Recurrence in multilocular lesions was more frequent than in unilocular lesions. Nine (64%) of 14 multilocular lesions recurred, in contrast to 2 (7%) of 27 unilocular lesions (p = 0.0350). The average length of recurrent lesions (62.8 ± 6.5 mm) was larger than that of nonrecurrent lesions (43.0 ± 4.0 mm; p = 0.0363). The immunoreactivity of proliferation-related SMO in KCOTs with recurrence was higher than that of those without recurrence (p = 0.0475), whereas the expressions of a ligand, SHH, and an inhibitory receptor, Patched, were not associated with KCOT recurrence. The expressions of SHH and SMO showed inverse correlation in whole KCOT (p = 0.0318). Conclusion: These findings suggest that recurrence of KCOT is associated with multilocular large lesions and high SMO expression.

        

]]> https://demo.discussdentistry.com/forums/topic/keratocystic-odontogenic-tumor-odontogenic-keratocyst/#post-14410 <![CDATA[Re: Keratocystic Odontogenic Tumor (Odontogenic Keratocyst)]]> https://demo.discussdentistry.com/forums/topic/keratocystic-odontogenic-tumor-odontogenic-keratocyst/#post-14410 Fri, 26 Nov 2010 05:55:54 +0000 tirath Treatment of large odontogenic keratocysts by decompression and later cystectomy

(1) Decompression results in new bone formation and thickening of the cyst wall. (2) This treatment conserves bone and anatomic structures. (3) The frequency of recurrence is low. (4) The keratocyst epithelium is modulated histologically to nonkeratocyst after decompression

        

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