Drug induced pigmentation

[sushantpatel_doc]

Etiology
•Antimalarials,
•tranquilizers,
• minocycline,
• azidothymidine,
• ketoconazole,
•phenolphthalein, and
•others are the most common drugs that induce pigmentation.

Clinical features

The clinical picture varies, and the condition may appear as irregular brown or black macules or plaques, or diffuse melanosis (Fig. ).
The buccal mucosa, tongue, palate, and gingiva are the most commonly affected sites.
The diagnosis is made on the basis of the history and clinical criteria.

Differential diagnosis

•Normal pigmentation,
• Addison disease,
• Peutz–Jeghers syndrome.

Treatment
• No treatment is required.

        

[sushantpatel_doc]

images

        

[Drsumitra]

Tetracyclines are teratogens due to the likelihood of causing teeth discolouration in the fetus as they develop in infancy. For this same reason, tetracyclines are contraindicated for use in children under 8 years of age. They are, however, safe to use in the first 18 weeks of pregnancy.

        

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