Oculodentodigital Dysplasia
Oculodentodigital dysplasia is an extremely rare genetic disease (with fewer than 1,000 people diagnosed worldwide) that affects the eyes, fingers and teeth. Common tooth abnormalities include small or missing teeth, numerous cavities, weak enamel and early tooth loss, according to the NIH. The condition can also lead to small eyes, vision loss, webbed skin and neurological problems. An autosomal dominant disorder, it develops when only one mutated gene is inherited from a parent.
Recombinant 8 Syndrome
Recombinant 8 syndrome is a rare disease of unknown incidence primarily affecting an Hispanic population descending from the San Luis Valley of Colorado and Northern New Mexico. Inherited in an autosomal dominant pattern, recombinant 8 syndrome causes distinctive facial abnormalities, moderate to severe intellectual disability and heart and urinary tract problems. Abnormal teeth, an overgrowth of gums, small chin, thin upper lip and downturned mouth are all associated with the condition, according to the NIH
.
