Implant Alpha Dent Active with 3D Active surface vs test-sample with RBM surface

The scientific workstation is a Phenom proX Scanning Electron Microscope, equipped with a high-sensitivity backscattered electron detector that allows compo- sitional and topographical imaging modes. EDX analyses are performed with a thermoelectrically cooled Silicon Drift Detector (SDD.) Without touching the surface, each implant will be taken out of the package with sterile forceps and will be fixed on the sample holders. After the vacuum is generated in the electron microscope imaging and EDXanalyses will be completed.

With a specific 3D roughness reconstruction application, based on a „shape from shading” technology, the SEM system used in this study is able to generate three- dimensional images and submicrometer roughness measurements. 3D imaging helps to interpret sample characteristics and makes images under- standable. In addition the system is able to measure the average roughness (Ra) and the roughness height (Rz). Due to shape-from-shading technology Ra and Rz data in this study are to be generally understood merely as approximate values.
The coloured “heatmap” in this report shows the digitally flattened larger structure of every region of interest (ROI) like
the concave valley of a thread or the convex structure of the outer ridge of the thread. The highest point in this texture is red (“hot”) and the deepest point is blue (cold). Three parallel lines along this structure perpendicular to the implant axis follow the 3-dimensional structure. The average Ra of these three lines allows to compare with the average Ra on the same ROI’s on other implants like the comparison object in this analysis.

Scanning electron microscopy (SEM) enables the topical evaluation of the implant surface. In particular at low voltages and small working distances, images with high contrast can be obtained. The high-sensitivity backscattered electron detector is generating images in compositional and topographical modes to a magnification of 20.000x. Besides information about morphology and surface topography, the BSE detector allows to draw conclusions about the chemical nature and allocation of different remnants or

SEM-COMPARISON OF IMPLANT ACTIVE WITH 3D ACTIVE SURFACE vs. TEST-SAMPLE WITH RBM SURFACE

SEM-Comparison of Implant body with 3d active surface vs implant with RBM surface

SEM-Comparison of implant thread with 3D Active surface vs implant with RBM surface

3D ROUGHNESS RECONSTRUCTION OF IMPLANT ACTIVE WITH 3D ACTIVE SURFACE
3D Roughness Reconstruction of Implant-Body (Peak)

3D ROUGHNESS RECONSTRUCTION – TEST-SAMPLE OF  IMPLANT BODY WITH RBM SURFACE
3D Roughness Reconstruction of Implant-Body (Peak)

Conclusions:
In comparison to the “Test-Sample” with RBM surface the “Implant Active” with 3D Active surface has a higher roughness in the area of the microthreads (in the valleys and peaks of the threads) and a higher roughness in the area of the implant body.

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The tablets offer a “laundry list” of advantages over a tube delivery system, according to Scott Jacobs, president of Archtek and creator of the Toothpaste Tablet.

“I’m dumbfounded that after 140 years we’re still dealing with the same delivery system.”
— Scott Jacobs, Artchtek president
“The first is sanitation because you’re not swiping the tube against a used brush, which transfers all the microbes from the brush onto the end of the tube,” he said. “There’s an environmental advantage because the product comes in a recyclable container. None of the toothpaste tubes on the market can be recycled, and there’s about 560 million per year in the U.S. alone that end up in landfills.”

The tablets, which come in 60-tablet bottles or boxes of 100 individually wrapped doses, are also tidy. “I have two boys, so I’ve lived with the mess toothpaste makes,” Jacobs laughed. “You’ve got goo on the sinks, the counter, the floor, inside the drawers. …”

Traversing Transportation Security Administration checkpoints at airports with the toothpaste tablets is easier than with traditional tubes since the dry tablets are not subject to the 3 oz. liquid limit guidelines for carry-on items.

“I’m dumbfounded that after 140 years we’re still dealing with the same delivery system,” Jacobs said. “So many advances have been made in other areas toward mobility, sanitation, and lessening environmental impact.”

The tablets contain cranberry extract (Exocyan), which reduces plaque, and xylitol to help mitigate the formation of caries. Two clinical studies, which are scheduled to be finished in June, are being performed at two different universities that Jacobs hopes will provide enough data for approval. He declined to name them until the studies are completed.

A clinical study conducted by Archtek provided enough evidence for the Dental Advisor to award it the Top Innovative Consumer Product of 2011 in January, according to Jacobs. The tablets received an 86% clinical rating from the Dental Advisor reviewers, with 57% saying they would recommend the product and 29% saying they would switch from a paste to the tablet.

8 years in the making

Jacobs first had the idea for a tablet-delivered dentifrice about eight years ago.

“I tried to introduce an effervescent tablet that created an amazing foaming action as soon as you put it in your mouth without ever needing a brush, but there were stability issues and expense-related ones,” he said.

The idea for a tablet stuck, however. “The more I thought about a tablet-based delivery system, the more the advantages became apparent,” he added.

Creating a cost-comparable product with similar dosing were two primary obstacles. The first aspect was overcome during research and development. Sorting out the matter of dosing and public perception will take more time.

“People often ask me, ‘How many uses do I get out of a tube of paste?’ ” Jacobs said. “The recommended dose is somewhere around 12 brushings per ounce. But because there’s never been anything different in the marketplace, the thought process of the public is, ‘How do I compare a 60-tablet bottle to a tube of paste. Is it equal to one? Two?’ They flat out don’t know.”

Jacobs referenced a recent Wall Street Journal article that reported the existence of more than 350 varieties of toothpaste. “It’s tough for the consumer to perceive the nuances between them,” he said.

Archtek, which was started in the 1960s by Jacobs’s father after he invented the boiling water mouthguard, is hoping to gain the ADA seal of approval for the tablets. Jacobs is also working to add the tablets to consumer store shelves; the Wal-Mart travel section will begin carrying the product in June. Archtek has also had a presence at dental and travel goods conventions while courting organizations such as Cardinal Health and smaller, independent pharmacies.

“We’re hitting everything from big boxes to brushing stations at dental offices,” Jacobs said. “It’s all about whether or not I can gain enough market acceptance early on before the really monster companies get into it.”

Other companies are marketing similar products, although so far not on the same scale that Jacobs is working to achieve. Akina’s Ceto-Q toothpaste tablets are being sold to travelers as a toothpaste alternative, and Lush, a U.K.-based cosmetics company, has launched a similar product in Europe that reportedly will be available in the U.S. beginning in June.